Immune Support in HPV Infection: What Role Do Products Designed for This Condition Play?
Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. There are approximately 200 types of the virus. Some can cause cancer or genital warts; however, not all are transmitted through sexual intercourse — transmission can also occur through contact of mucous membranes and skin. During their lifetime, up to 80% of people will encounter an HPV infection. Persistent infections, particularly high-risk HPV types, may lead to serious health complications, including cervical cancer. Unfortunately, there is no cure for HPV, which is why strengthening the immune system is crucial in the prevention and management of HPV infection. Diseases caused by the feared HPV virus are important to detect and treat early. (3)
The Role of Immunity in HPV Infection
The immune system plays a decisive role in eliminating HPV infection. A strong and effective immune response can prevent the infection from progressing to a chronic stage. Conversely, weakened immunity may allow the virus to persist and increase the risk of developing precancerous lesions and cancer. Factors such as stress, smoking, lack of sleep, and an unbalanced diet can negatively affect the body’s immune response. Therefore, it is important to maintain a healthy lifestyle and, when necessary, support the immune system with appropriate dietary supplements. (5)
Products for the Prevention and Treatment of HPV-Related Lesions
There are many dietary supplements and natural products available on the market that claim to support the immune system in the fight against HPV.
Vitamins
Folic acid, vitamin B12, and vitamin D are important for the proper functioning of the immune system. Deficiency of these vitamins may weaken the immune response to HPV. Higher plasma levels of folic acid may reduce the risk of HPV infection by up to 73%. (4)
AHCC
AHCC is an extract from the mycelia of the shiitake mushroom, used in Japan to support immunity. Studies suggest that it may help the body eliminate high-risk HPV types. Several additional studies in animals and humans have demonstrated various therapeutic effects, including enhanced antioxidant effects, anticancer activity, and modulation of the immune system to prevent infectious processes caused by both viral and bacterial infections. (5)
EGCG (Epigallocatechin gallate)
This is a highly concentrated and potent antioxidant found in green tea. Studies show that it may help prevent persistent HPV infections and support cervical health. This natural molecule, known for its antioxidant, anti-inflammatory, and antitumor activity, may prevent cancer progression and strengthen innate antiviral immunity against HPV. (4)
Iside HPV
A medical device, Iside HPV, has been specifically developed for the prevention and treatment of lesions caused by HPV. These are vaginal suppositories intended to support the health of the cervix and vaginal mucosa, particularly in women with HPV infection. Its formulation is designed to support the body’s natural defense mechanisms and contribute to mucosal regeneration. (1)
Iside HPV contains a combination of natural substances with a synergistic effect:
PrincipHYAL® (full-spectrum sodium hyaluronate): supports mucosal regeneration and hydration, improves elasticity and healing.
Lactic acid and citric acid: help maintain the natural acidic pH of the vaginal environment, creating unfavorable conditions for the spread of pathogenic microorganisms, including HPV.
Arabinogalactan: a polysaccharide fiber with a prebiotic effect, meaning it supports the growth of lactobacilli, which are part of the vaginal environment.
Zinc citrate: a source of zinc that activates T-lymphocyte-mediated immune response and reduces the risk of long-term HPV infection. (1)
Together, these components contribute to the restoration and protection of the vaginal mucosa, formation of a protective intravaginal film, prevention of HPV penetration and integration, support of cervical re-epithelialization, and improvement of lesion healing. (2)
Recommended dosage: One suppository daily for 14 consecutive days starting after the end of menstruation, repeated for 3 months. (2)
Supporting the immune system is key in managing HPV infection. Dietary supplements and products such as Iside HPV may be helpful, but they should be part of a comprehensive approach that includes a healthy lifestyle, regular medical check-ups, and consultation with healthcare professionals. Before starting any dietary supplements or products, it is important to consult a physician or pharmacist.
List of References:
The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report (https://pmc.ncbi.nlm.nih.gov/articles/PMC10051187/)
New Phase II Clinical Trial Suggests that Mushroom-Derived AHCC Is Effective at Clearing Persistent HPV Infections (https://hpvca.org/ahcc-shown-to-clear-hpv-infections/)
